Ontology highlight
ABSTRACT:
SUBMITTER: Campbell MG
PROVIDER: S-EPMC4391500 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
eLife 20150311
Recent developments in detector hardware and image-processing software have revolutionized single particle cryo-electron microscopy (cryoEM) and led to a wave of near-atomic resolution (typically ∼3.3 Å) reconstructions. Reaching resolutions higher than 3 Å is a prerequisite for structure-based drug design and for cryoEM to become widely interesting to pharmaceutical industries. We report here the structure of the 700 kDa Thermoplasma acidophilum 20S proteasome (T20S), determined at 2.8 Å resolu ...[more]