Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.
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ABSTRACT:
SUBMITTER: Kimata N
PROVIDER: S-EPMC4391883 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.
Kimata Naoki N Reeves Philip J PJ Smith Steven O SO
Journal of magnetic resonance (San Diego, Calif. : 1997) 20150401
G protein-coupled receptors (GPCRs) span cell membranes with seven transmembrane helices and respond to a diverse array of extracellular signals. Crystal structures of GPCRs have provided key insights into the architecture of these receptors and the role of conserved residues. However, the question of how ligand binding induces the conformational changes that are essential for activation remains largely unanswered. Since the extracellular sequences and structures of GPCRs are not conserved betwe ...[more]
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