Pharmacodynamics must inform statistics: an example from a cocaine dependence pharmacotherapy trial.
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ABSTRACT:
SUBMITTER: Winhusen TM
PROVIDER: S-EPMC4392966 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Pharmacodynamics must inform statistics: an example from a cocaine dependence pharmacotherapy trial.
Winhusen Theresa M TM Lewis Daniel F DF Somoza Eugene C EC Horn Paul P
ISRN Addiction 20140205
Background. There is no FDA-approved medication for cocaine dependence or consensus on the statistical approach for analyzing data from cocaine dependence pharmacotherapy trials. The goal of this paper is to illustrate the importance of understanding medication's pharmacodynamics when specifying the statistical model to test its efficacy. Method. Data from a double-blind placebo controlled trial of reserpine for cocaine dependence are analyzed. Since the antihypertensive properties of reserpine ...[more]
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