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MicroRNA-like small RNAs prediction in the development of Antrodia cinnamomea.


ABSTRACT: Antrodia cinnamomea, a precious, host-specific brown-rot fungus that has been used as a folk medicine in Taiwan for centuries is known to have diverse bioactive compounds with potent pharmaceutical activity. In this study, different fermentation states of A. cinnamomea (wild-type fruiting bodies and liquid cultured mycelium) were sequenced using the next-generation sequencing (NGS) technique. A 45.58 Mb genome encoding 6,522 predicted genes was obtained. High quality reads were assembled into a total of 13,109 unigenes. Using a previously constructed pipeline to search for microRNAs (miRNAs), we then identified 4 predicted conserved miRNA and 63 novel predicted miRNA-like small RNA (milRNA) candidates. Target prediction revealed several interesting proteins involved in tri-terpenoid synthesis, mating type recognition, chemical or physical sensory protein and transporters predicted to be regulated by the miRNAs and milRNAs.

SUBMITTER: Lin YL 

PROVIDER: S-EPMC4393119 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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MicroRNA-like small RNAs prediction in the development of Antrodia cinnamomea.

Lin Yan-Liang YL   Ma Li-Ting LT   Lee Yi-Ru YR   Lin Shih-Shun SS   Wang Sheng-Yang SY   Chang Tun-Tschu TT   Shaw Jei-Fu JF   Li Wen-Hsiung WH   Chu Fang-Hua FH  

PloS one 20150410 4


Antrodia cinnamomea, a precious, host-specific brown-rot fungus that has been used as a folk medicine in Taiwan for centuries is known to have diverse bioactive compounds with potent pharmaceutical activity. In this study, different fermentation states of A. cinnamomea (wild-type fruiting bodies and liquid cultured mycelium) were sequenced using the next-generation sequencing (NGS) technique. A 45.58 Mb genome encoding 6,522 predicted genes was obtained. High quality reads were assembled into a  ...[more]

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