Ontology highlight
ABSTRACT:
SUBMITTER: Shrivastava R
PROVIDER: S-EPMC4393143 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Shrivastava Rohini R Köster Darius D Kalme Sheetal S Mayor Satyajit S Neerathilingam Muniasamy M
PloS one 20150410 4
Ezrin, a member of the ERM (Ezrin/Radixin/Moesin) protein family, is an Actin-plasma membrane linker protein mediating cellular integrity and function. In-vivo study of such interactions is a complex task due to the presence of a large number of endogenous binding partners for both Ezrin and Actin. Further, C-terminal actin binding capacity of the full length Ezrin is naturally shielded by its N-terminal, and only rendered active in the presence of Phosphatidylinositol bisphosphate (PIP2) or pho ...[more]