Emotion-motion interactions in conversion disorder: an FMRI study.
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ABSTRACT: Objectives
To evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients.Methods
An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups.Results
We found increased amygdala activation to negative emotions in CD compared to healthy controls in region of interest analyses, which persisted over time consistent with previous findings using emotional paradigms. Furthermore during whole brain analyses we found significantly increased activation in CD patients in areas involved in the 'freeze response' to fear (periaqueductal grey matter), and areas involved in self-awareness and motor control (cingulate gyrus and supplementary motor area).Conclusions
In contrast to healthy controls, CD patients exhibited increased response amplitude to fearful stimuli over time, suggesting abnormal emotional regulation (failure of habituation / sensitization). Patients with CD also activated midbrain and frontal structures that could reflect an abnormal behavioral-motor response to negative including threatening stimuli. This suggests a mechanism linking emotions to motor dysfunction in CD.
SUBMITTER: Aybek S
PROVIDER: S-EPMC4393246 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Emotion-motion interactions in conversion disorder: an FMRI study.
Aybek Selma S Nicholson Timothy R TR O'Daly Owen O Zelaya Fernando F Kanaan Richard A RA David Anthony S AS
PloS one 20150410 4
<h4>Objectives</h4>To evaluate the neural correlates of implicit processing of negative emotions in motor conversion disorder (CD) patients.<h4>Methods</h4>An event related fMRI task was completed by 12 motor CD patients and 14 matched healthy controls using standardised stimuli of faces with fearful and sad emotional expressions in comparison to faces with neutral expressions. Temporal changes in the sensitivity to stimuli were also modelled and tested in the two groups.<h4>Results</h4>We found ...[more]
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