Dataset Information

Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

ABSTRACT:

Objective

To compare incidence of first osteoporotic fracture in two cohorts of postmenopausal women, one treated with bisphosphonates and the other only with calcium and vitamin D.

Design

Retrospective population cohort study with paired matching based on data from electronic health records.

Setting

Women aged 60 years and older in 2005, from 21 primary care centers in a healthcare region of Spain.

Participants

Two groups of women aged 60 years and older (n = 1208), prescribed either calcium and vitamin D (CalVitD) or bisphosphonates (BIPHOS) with or without calcium and vitamin D, were compared for the end point of first recorded osteoporotic-related fracture, with 5-years follow-up.

Main outcome measure

Incidence of first fracture: Vertebral fracture, osteoporosis with pathological fracture, fracture of the upper humeral epiphysis, fracture of the lower radial epiphysis, or femur fracture.

Results

Estimated 10-year risk of fracture was 11.4% (95% confidence interval: 9.6 to 13.2), 11.8% (9.2 to 14.3) in the BIPHOS group and 11.1% (8.6 to 13.6) in the CalVitD group. No significant differences were found between groups in total fractures (Hazard ratio = 0.934 (0.67 to 1.31)) or location (vertebral, femoral, radial or humeral).

Conclusions

In postmenopausal women, bisphosphonates have not been shown to better decrease risk of first fracture compared with calcium and vitamin D therapy alone.

SUBMITTER: Real J

PROVIDER: S-EPMC4393307 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

Real Jordi J Galindo Gisela G Galván Leonardo L Lafarga María Antonia MA Rodrigo María Dolors MD Ortega Marta M

PloS one 20150410 4

<h4>Objective</h4>To compare incidence of first osteoporotic fracture in two cohorts of postmenopausal women, one treated with bisphosphonates and the other only with calcium and vitamin D.<h4>Design</h4>Retrospective population cohort study with paired matching based on data from electronic health records.<h4>Setting</h4>Women aged 60 years and older in 2005, from 21 primary care centers in a healthcare region of Spain.<h4>Participants</h4>Two groups of women aged 60 years and older (n = 1208), ...[more]

PMID: 25861000

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Dataset Information

Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

Objective

Design

Setting

Participants

Main outcome measure

Results

Conclusions

Publications

Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study.

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