Unknown

Dataset Information

0

Genetic polymorphisms associated with breast cancer in malaysian cohort.

ABSTRACT: Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case-control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ? 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.

SUBMITTER: Chahil JK 

PROVIDER: S-EPMC4393382 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genetic polymorphisms associated with breast cancer in malaysian cohort.

Chahil Jagdish Kaur JK   Munretnam Khamsigan K   Samsudin Nurulhafizah N   Lye Say Hean SH   Hashim Nikman Adli Nor NA   Ramzi Nurul Hanis NH   Velapasamy Sharmila S   Wee Ler Lian LL   Alex Livy L  

Indian journal of clinical biochemistry : IJCB 20140123 2

Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case-control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and prote  ...[more]

Similar Datasets

Unknown Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases.
| S-EPMC1215495 | biostudies-literature
Unknown Hypercholesterolemia in the Malaysian Cohort Participants: Genetic and Non-Genetic Risk Factors.
| S-EPMC10048611 | biostudies-literature
Unknown Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women.
| S-EPMC6325673 | biostudies-literature
Unknown Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
| S-EPMC2729775 | biostudies-literature
Unknown Vitamin D-associated genetic variation and risk of breast cancer in the breast and prostate cancer cohort consortium (BPC3).
| S-EPMC4355227 | biostudies-literature
Unknown Genetic polymorphisms in the androgen metabolism pathway and risk of prostate cancer in low incidence Malaysian ethnic groups.
| S-EPMC4694459 | biostudies-literature
Unknown Circadian Gene Polymorphisms Associated with Breast Cancer Susceptibility.
| S-EPMC6888181 | biostudies-literature
Unknown Using Breast Cancer Risk Associated Polymorphisms to Identify Women for Breast Cancer Chemoprevention.
| S-EPMC5249071 | biostudies-literature
Unknown Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer.
| S-EPMC3907692 | biostudies-literature
Unknown TCF21 genetic polymorphisms and breast cancer risk in Chinese women.
| S-EPMC5342451 | biostudies-literature