A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes.

ABSTRACT:

Background

In this study we performed genome-wide association studies to identify candidate SNPs that may predict the risk of disease outcome in colorectal cancer.

Methods

Patient cohort consisted of 505 unrelated patients with Caucasian ancestry. Germline DNA samples were genotyped using the Illumina® human Omni-1quad SNP chip. Associations of SNPs with overall and disease free survivals were examined primarily for 431 patients with microsatellite instability-low (MSI-L) or stable (MSS) colorectal tumors using Cox proportional hazards method adjusting for clinical covariates. Bootstrap method was applied for internal validation of results. As exploratory analyses, association analyses for the colon (n = 334) and rectal (n = 171) cancer patients were also performed.

Resul

SUBMITTER: Xu W 

PROVIDER: S-EPMC4393623 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature