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A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes.

ABSTRACT: BACKGROUND:In this study we performed genome-wide association studies to identify candidate SNPs that may predict the risk of disease outcome in colorectal cancer. METHODS:Patient cohort consisted of 505 unrelated patients with Caucasian ancestry. Germline DNA samples were genotyped using the Illumina® human Omni-1quad SNP chip. Associations of SNPs with overall and disease free survivals were examined primarily for 431 patients with microsatellite instability-low (MSI-L) or stable (MSS) colorectal tumors using Cox proportional hazards method adjusting for clinical covariates. Bootstrap method was applied for internal validation of results. As exploratory analyses, association analyses for the colon (n?=?334) and rectal (n?=?171) cancer patients were also performed. RESULTS:As a result, there was no SNP that reached the genomewide significance levels (p?

SUBMITTER: Xu W

PROVIDER: S-EPMC4393623 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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A genome wide association study on Newfoundland colorectal cancer patients' survival outcomes.

Xu Wei W Xu Jingxiong J Shestopaloff Konstantin K Dicks Elizabeth E Green Jane J Parfrey Patrick P Green Roger R Savas Sevtap S

Biomarker research 20150319

<h4>Background</h4>In this study we performed genome-wide association studies to identify candidate SNPs that may predict the risk of disease outcome in colorectal cancer.<h4>Methods</h4>Patient cohort consisted of 505 unrelated patients with Caucasian ancestry. Germline DNA samples were genotyped using the Illumina® human Omni-1quad SNP chip. Associations of SNPs with overall and disease free survivals were examined primarily for 431 patients with microsatellite instability-low (MSI-L) or stabl ...[more]

PMID: 25866641

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