Ontology highlight
ABSTRACT:
SUBMITTER: Guimaraes JS
PROVIDER: S-EPMC4393762 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Guimarães Jacqueline S JS Cominal Juçara G JG Silva-Pinto Ana Cristina AC Olbina Gordana G Ginzburg Yelena Z YZ Nandi Vijay V Westerman Mark M Rivella Stefano S de Souza Ana Maria AM
European journal of haematology 20141111 6
The thalassemia syndromes (α- and β-thalassemia) are the most common and frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, and more erythroid progenitors in the blood stream. While patients affected by these disorders show definitive altered parameters related to erythropoiesis, the relationship between the degree of anemia, altered erythropoiesis, and dysfunctional iron metabolism has ...[more]