Ontology highlight
ABSTRACT:
SUBMITTER: Pei L
PROVIDER: S-EPMC4393848 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Pei Liming L Mu Yangling Y Leblanc Mathias M Alaynick William W Barish Grant D GD Pankratz Matthew M Tseng Tiffany W TW Kaufman Samantha S Liddle Christopher C Yu Ruth T RT Downes Michael M Pfaff Samuel L SL Auwerx Johan J Gage Fred H FH Evans Ronald M RM
Cell metabolism 20150401 4
Neurons utilize mitochondrial oxidative phosphorylation (OxPhos) to generate energy essential for survival, function, and behavioral output. Unlike most cells that burn both fat and sugar, neurons only burn sugar. Despite its importance, how neurons meet the increased energy demands of complex behaviors such as learning and memory is poorly understood. Here we show that the estrogen-related receptor gamma (ERRγ) orchestrates the expression of a distinct neural gene network promoting mitochondria ...[more]