Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Sieiro P
PROVIDER: S-EPMC4393947 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Applied microbiology and biotechnology 20140422 15
Prolyl endopeptidases (PEP) (EC 3.4.21.26), a family of serine proteases with the ability to hydrolyze the peptide bond on the carboxyl side of an internal proline residue, are able to degrade immunotoxic peptides responsible for celiac disease (CD), such as a 33-residue gluten peptide (33-mer). Oral administration of PEP has been suggested as a potential therapeutic approach for CD, although delivery of the enzyme to the small intestine requires intrinsic gastric stability or advanced formulati ...[more]