Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4394755 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhang Huaqun H Zhou Chen C Chen Wuyan W Xu Yechun Y Shi Yanhong Y Wen Yi Y Zhang Naixia N
Scientific reports 20150413
Heat-shock protein 90 (Hsp90) is one of the most important chaperones involved in multiple cellular processes. The chaperoning function of Hsp90 is intimately coupled to the ATPase activity presented by its N-terminal domain. However, the molecular mechanism for the ATP-dependent working cycle of Hsp90 is still not fully understood. In this study, we use NMR techniques to investigate the structural characteristics and dynamic behaviors of Hsp90 N-terminal domain in its free and AMPPCP (ATP analo ...[more]