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Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.

ABSTRACT: Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.

SUBMITTER: Cheng YH 

PROVIDER: S-EPMC4394772 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.

Cheng Yi-Hsiang YH   Lin Tzu-Lung TL   Pan Yi-Jiun YJ   Wang Yu-Ping YP   Lin Yi-Tsung YT   Wang Jin-Town JT  

Antimicrobial agents and chemotherapy 20150217 5

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu  ...[more]

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