Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human.
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ABSTRACT:
SUBMITTER: Perez LM
PROVIDER: S-EPMC4395137 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human.
Pérez Laura M LM Bernal Aurora A de Lucas Beatriz B San Martin Nuria N Mastrangelo Annalaura A García Antonia A Barbas Coral C Gálvez Beatriz G BG
PloS one 20150413 4
Adipose stem cells (ASCs) are an appealing source of cells for therapeutic intervention; however, the environment from which ASCs are isolated may impact their usefulness. Using a range of functional assays, we have evaluated whether ASCs isolated from an obese environment are comparable to cells from non-obese adipose tissue. Results showed that ASCs isolated from obese tissue have a reduced proliferative ability and a loss of viability together with changes in telomerase activity and DNA telom ...[more]
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