Ontology highlight
ABSTRACT:
SUBMITTER: Bradford RD
PROVIDER: S-EPMC4395355 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Bradford Russell D RD Yoo Young-Gun YG Golemac Mijo M Pugel Ester Pernjak EP Jonjic Stipan S Britt William J WJ
PLoS pathogens 20150413 4
Congenital human cytomegalovirus (HCMV) occurs in 0.5-1% of live births and approximately 10% of infected infants develop hearing loss. The mechanism(s) of hearing loss remain unknown. We developed a murine model of CMV induced hearing loss in which murine cytomegalovirus (MCMV) infection of newborn mice leads to hematogenous spread of virus to the inner ear, induction of inflammatory responses, and hearing loss. Characteristics of the hearing loss described in infants with congenital HCMV infec ...[more]