Ontology highlight
ABSTRACT:
SUBMITTER: Tsaalbi-Shtylik A
PROVIDER: S-EPMC4395481 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Tsaalbi-Shtylik Anastasia A Ferrás Cristina C Pauw Bea B Hendriks Giel G Temviriyanukul Piya P Carlée Leone L Calléja Fabienne F van Hees Sandrine S Akagi Jun-Ichi J Iwai Shigenori S Hanaoka Fumio F Jansen Jacob G JG de Wind Niels N
The Journal of cell biology 20150401 1
In addition to correcting mispaired nucleotides, DNA mismatch repair (MMR) proteins have been implicated in mutagenic, cell cycle, and apoptotic responses to agents that induce structurally aberrant nucleotide lesions. Here, we investigated the mechanistic basis for these responses by exposing cell lines with single or combined genetic defects in nucleotide excision repair (NER), postreplicative translesion synthesis (TLS), and MMR to low-dose ultraviolet light during S phase. Our data reveal th ...[more]