Ontology highlight
ABSTRACT:
SUBMITTER: Okatsu K
PROVIDER: S-EPMC4395490 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Okatsu Kei K Koyano Fumika F Kimura Mayumi M Kosako Hidetaka H Saeki Yasushi Y Tanaka Keiji K Matsuda Noriyuki N
The Journal of cell biology 20150406 1
PINK1 selectively recruits Parkin to depolarized mitochondria for quarantine and removal of damaged mitochondria via ubiquitylation. Dysfunction of this process predisposes development of familial recessive Parkinson's disease. Although various models for the recruitment process have been proposed, none of them adequately explain the accumulated data, and thus the molecular basis for PINK1 recruitment of Parkin remains to be fully elucidated. In this study, we show that a linear ubiquitin chain ...[more]