Ontology highlight
ABSTRACT:
SUBMITTER: Gray LR
PROVIDER: S-EPMC4395859 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Gray Lachlan R LR Gabuzda Dana D Cowley Daniel D Ellett Anne A Chiavaroli Lisa L Wesselingh Steven L SL Churchill Melissa J MJ Gorry Paul R PR
Journal of neurovirology 20101130 1
Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dementia (HAD) is unclear. In this study, we characterized 82 nef alleles cloned from brain, cerebral spinal fluid, spinal cord, and blood/lymphoid tissue-derived HIV-1 isolates from seve ...[more]