White and gray matter contributions to executive function recovery after traumatic brain injury.

ABSTRACT:

Objective

We investigated the association between regional white and gray matter volume loss and performance on executive functions (EFs) in patients with penetrating traumatic brain injury (pTBI).

Methods

We studied 164 pTBI patients and 43 healthy controls from the Vietnam Head Injury Study. We acquired CT scans for pTBI patients and divided them according to lesion localization (left and right prefrontal cortex [PFC]). We administered EF tests (Verbal Fluency, Trail Making, Twenty Questions) and used voxel-based lesion symptom mapping (VLSM) and group-based correlational and multiple regression analyses to examine the relative influence of gray and white matter lesions on EF recovery.

Results

The VLSM analysis revealed that white and gray white matter lesions were

SUBMITTER: Cristofori I 

PROVIDER: S-EPMC4395886 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature