Synthetically defined glycoprotein vaccines: current status and future directions.
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ABSTRACT:
SUBMITTER: Adamo R
PROVIDER: S-EPMC4396375 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
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Synthetically defined glycoprotein vaccines: current status and future directions.
Adamo Roberto R Nilo Alberto A Castagner Bastien B Boutureira Omar O Berti Francesco F Bernardes Gonçalo J L GJ
Chemical science 20130516 8
Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to furth ...[more]
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