Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka K
PROVIDER: S-EPMC4396477 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Tanaka Kazuhiro K Sasayama Takashi T Irino Yasuhiro Y Takata Kumi K Nagashima Hiroaki H Satoh Naoko N Kyotani Katsusuke K Mizowaki Takashi T Imahori Taichiro T Ejima Yasuo Y Masui Kenta K Gini Beatrice B Yang Huijun H Hosoda Kohkichi K Sasaki Ryohei R Mischel Paul S PS Kohmura Eiji E
The Journal of clinical investigation 20150323 4
The mechanistic target of rapamycin (mTOR) is hyperactivated in many types of cancer, rendering it a compelling drug target; however, the impact of mTOR inhibition on metabolic reprogramming in cancer is incompletely understood. Here, by integrating metabolic and functional studies in glioblastoma multiforme (GBM) cell lines, preclinical models, and clinical samples, we demonstrate that the compensatory upregulation of glutamine metabolism promotes resistance to mTOR kinase inhibitors. Metabolom ...[more]