Distinct metabolomic signatures are associated with longevity in humans.
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ABSTRACT:
SUBMITTER: Cheng S
PROVIDER: S-EPMC4396657 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Distinct metabolomic signatures are associated with longevity in humans.
Cheng Susan S Larson Martin G MG McCabe Elizabeth L EL Murabito Joanne M JM Rhee Eugene P EP Ho Jennifer E JE Jacques Paul F PF Ghorbani Anahita A Magnusson Martin M Souza Amanda L AL Deik Amy A AA Pierce Kerry A KA Bullock Kevin K O'Donnell Christopher J CJ Melander Olle O Clish Clary B CB Vasan Ramachandran S RS Gerszten Robert E RE Wang Thomas J TJ
Nature communications 20150413
Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. Highe ...[more]
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