Ontology highlight
ABSTRACT:
SUBMITTER: Balenga NA
PROVIDER: S-EPMC4396684 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Balenga Nariman A NA Klichinsky Michael M Xie Zhihui Z Chan Eunice C EC Zhao Ming M Jude Joseph J Laviolette Michel M Panettieri Reynold A RA Druey Kirk M KM
Nature communications 20150413
Asthma, a common disorder that affects >250 million people worldwide, is defined by exaggerated bronchoconstriction to inflammatory mediators including acetylcholine (ACh), bradykinin and histamine-also termed airway hyper-responsiveness. Nearly 10% of people with asthma have severe, treatment-resistant disease, which is frequently associated with immunoglobulin-E sensitization to ubiquitous fungi, typically Aspergillus fumigatus (Af). Here we show that a major Af allergen, Asp f13, which is a s ...[more]