Ontology highlight
ABSTRACT:
SUBMITTER: Srivatsal S
PROVIDER: S-EPMC4397146 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Movement disorders : official journal of the Movement Disorder Society 20150204 5
<h4>Background</h4>Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized.<h4>Methods</h4>A cohort of 1,447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for LRRK2 mutations and completed detailed cognitive testing. Associations be ...[more]