Ontology highlight
ABSTRACT: Objective
P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population.Methods
Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk factors, coronary artery calcium (CAC), intima-media thickness, and CHD. Regression models were used to investigate the association between P-selectin and risk factors, Tobit model for CAC, and Cox regression for CHD events.Results
Mean levels of P-selectin differed by ethnicity and were higher in men (P<0.001). For all ethnic groups, P-selectin was positively associated with measures of adiposity, blood pressure, current smoking, LDL, and triglycerides and inversely with HDL. A significant ethnic interaction was observed for the association of P-selectin and prevalent diabetes; however, P-selectin was positively associated with HbA1c in all groups. Higher P-selectin levels were associated with greater prevalence of CAC. Over 10.1 years of follow-up, there were 335 incident CHD events. There was a positive linear association between P-selectin levels and rate of incident CHD after adjustment for traditional risk factors. However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027).Conclusion
We observed ethnic heterogeneity in the association of P-selectin and risk of CHD.
SUBMITTER: Bielinski SJ
PROVIDER: S-EPMC4397161 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Bielinski Suzette J SJ Berardi Cecilia C Decker Paul A PA Kirsch Phillip S PS Larson Nicholas B NB Pankow James S JS Sale Michele M de Andrade Mariza M Sicotte Hugues H Tang Weihong W Hanson Naomi Q NQ Wassel Christina L CL Polak Joseph F JF Tsai Michael Y MY
Atherosclerosis 20150223 1
<h4>Objective</h4>P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population.<h4>Methods</h4>Data from the Multi-Ethnic Study of Atherosclerosis (MESA), including 1628 African, 702 Chinese, 2393 non-Hispanic white, and 1302 Hispanic Americans, were used to investigate the association of plasma P-selectin with CHD risk fa ...[more]