Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
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ABSTRACT:
SUBMITTER: Lewis HD
PROVIDER: S-EPMC4397581 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Lewis Huw D HD Liddle John J Coote Jim E JE Atkinson Stephen J SJ Barker Michael D MD Bax Benjamin D BD Bicker Kevin L KL Bingham Ryan P RP Campbell Matthew M Chen Yu Hua YH Chung Chun-Wa CW Craggs Peter D PD Davis Rob P RP Eberhard Dirk D Joberty Gerard G Lind Kenneth E KE Locke Kelly K Maller Claire C Martinod Kimberly K Patten Chris C Polyakova Oxana O Rise Cecil E CE Rüdiger Martin M Sheppard Robert J RJ Slade Daniel J DJ Thomas Pamela P Thorpe Jim J Yao Gang G Drewes Gerard G Wagner Denisa D DD Thompson Paul R PR Prinjha Rab K RK Wilson David M DM
Nature chemical biology 20150126 3
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored. ...[more]
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