Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki N
PROVIDER: S-EPMC4397902 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Suzuki Naoki N Maroof Asif M AM Merkle Florian T FT Koszka Kathryn K Intoh Atsushi A Armstrong Ian I Moccia Rob R Davis-Dusenbery Brandi N BN Eggan Kevin K
Nature neuroscience 20131103 12
Using transgenic mice harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog (3110043O21Rik). Unlike most genes that are mutated in amyotrophic lateral sclerosis (ALS), which are ubiquitously expressed, the C9ORF72 ortholog was most highly transcribed in the neuronal populations that are sensitive to degeneration in ALS and frontotemporal dementia. Thus, our results provide a potential explanation for the cell type specificity of neuronal degeneratio ...[more]