Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC4398576 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Mucosal immunology 20141015 3
Vitamin D receptor (VDR) knockout (KO) mice had fewer Citrobacter rodentium in the feces than wild-type (WT) mice and the kinetics of clearance was faster in VDR KO than WT mice. VDR KO mice had more interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) and more antibacterial peptides than WT mice. The increased ILCs in the VDR KO mice was a cell-autonomous effect of VDR deficiency on ILC frequencies. Bone marrow (BM) transplantation from VDR KO mice into WT resulted in higher ILCs and c ...[more]