Ontology highlight
ABSTRACT:
SUBMITTER: Jameson JB
PROVIDER: S-EPMC4398643 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Jameson J Brian JB Kenyon Victor V Holman Theodore R TR
Analytical biochemistry 20150221
Lipoxygenases (LOXs) regulate inflammation through the production of a variety of molecules whose specific downstream effects are not entirely understood due to the complexity of the inflammation pathway. The generation of these biomolecules can potentially be inhibited and/or allosterically regulated by small synthetic molecules. The current work describes the first mass spectrometric high-throughput method for identifying small molecule LOX inhibitors and LOX allosteric effectors that change t ...[more]