Ontology highlight
ABSTRACT:
SUBMITTER: Gergics P
PROVIDER: S-EPMC4399274 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Gergics Peter P Brinkmeier Michelle L ML Camper Sally A SA
Molecular endocrinology (Baltimore, Md.) 20150210 4
Defects in the Lhx4, Lhx3, and Pitx2 genes can cause combined pituitary hormone deficiency and pituitary hypoplasia in both humans and mice. Not much is known about the mechanism underlying hypoplasia in these mutants beyond generally increased cell death and poorly maintained proliferation. We identified both common and unique abnormalities in developmental regulation of key cell cycle regulator gene expression in each of these three mutants. All three mutants exhibit reduced expression of the ...[more]