Ontology highlight
ABSTRACT:
SUBMITTER: Merkling SH
PROVIDER: S-EPMC4399909 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Merkling Sarah H SH Bronkhorst Alfred W AW Kramer Jamie M JM Overheul Gijs J GJ Schenck Annette A Van Rij Ronald P RP
PLoS pathogens 20150416 4
Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependen ...[more]