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The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila.


ABSTRACT: Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependent responses, but not with major differences in viral load. Genetic experiments indicate that hyperactivated Jak-Stat responses are associated with early lethality in virus-infected flies. Our results identify an essential epigenetic mechanism underlying tolerance to virus infection.

SUBMITTER: Merkling SH 

PROVIDER: S-EPMC4399909 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila.

Merkling Sarah H SH   Bronkhorst Alfred W AW   Kramer Jamie M JM   Overheul Gijs J GJ   Schenck Annette A   Van Rij Ronald P RP  

PLoS pathogens 20150416 4


Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependen  ...[more]

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