Ontology highlight
ABSTRACT:
SUBMITTER: Drobnak I
PROVIDER: S-EPMC4400326 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Drobnak Igor I Braselmann Esther E Clark Patricia L PL
The Journal of biological chemistry 20150210 16
Autotransporter (AT) proteins are a broad class of virulence proteins from Gram-negative bacterial pathogens that require their own C-terminal transmembrane domain to translocate their N-terminal passenger across the bacterial outer membrane (OM). But given the unavailability of ATP or a proton gradient across the OM, it is unknown what energy source(s) drives this process. Here we used a combination of computational and experimental approaches to quantitatively compare proposed AT OM translocat ...[more]