Systemic amyloidosis: lessons from ?2-microglobulin.
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ABSTRACT:
SUBMITTER: Stoppini M
PROVIDER: S-EPMC4400370 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Systemic amyloidosis: lessons from β2-microglobulin.
Stoppini Monica M Bellotti Vittorio V
The Journal of biological chemistry 20150306 16
β2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic amyloidosis. These two types of amyloidoses differ significantly in terms of the tissue localization of deposits and for major pathological features. Considering how the amyloidogenesis of the β2-microglobulin mechanism has been scrutinized in depth for the last three decades, the comparative analysis of molecular and ...[more]
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