Neutrophil extracellular trap components in fibrinoid necrosis of the kidney with myeloperoxidase-ANCA-associated vasculitis.
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ABSTRACT:
SUBMITTER: Yoshida M
PROVIDER: S-EPMC4400491 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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Neutrophil extracellular trap components in fibrinoid necrosis of the kidney with myeloperoxidase-ANCA-associated vasculitis.
Yoshida Masaharu M Sasaki Mariko M Sugisaki Kentaro K Yamaguchi Yutaka Y Yamada Michiyuki M
Clinical kidney journal 20130601 3
In response to antineutrophil cytoplasmic antibody (ANCA), activated neutrophils release decondensed chromatin associated with cytoplasmic granular proteins composed of proteolytic enzymes and myeloperoxidase (MPO); these complexes are named neutrophil extracellular traps (NETs). NET formation requires peptidylarginine deiminase 4 (PAD4) to citrullinate chromatin histones and also MPO and neutrophil elastase to aid in decondensation and release of chromatin. Immunostaining of renal biopsy reveal ...[more]
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