Ontology highlight
ABSTRACT:
SUBMITTER: Lindstrom NO
PROVIDER: S-EPMC4400645 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Lindström Nils Olof NO Carragher Neil Oliver NO Hohenstein Peter P
Stem cell reports 20150305 4
Nephron progenitor cells differentiate to form nephrons during embryonic kidney development. In contrast, self-renewal maintains progenitor numbers and premature depletion leads to impaired kidney function. Here we analyze the PI3K pathway as a point of convergence for the multiple pathways that are known to control self-renewal in the kidney. We demonstrate that a reduction in PI3K signaling triggers premature differentiation of the progenitors and activates a differentiation program that prece ...[more]