Ontology highlight
ABSTRACT:
SUBMITTER: Spahn JH
PROVIDER: S-EPMC4401083 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Spahn Jessica H JH Li Wenjun W Bribriesco Alejandro C AC Liu Jie J Shen Hua H Ibricevic Aida A Pan Jie-Hong JH Zinselmeyer Bernd H BH Brody Steven L SL Goldstein Daniel R DR Krupnick Alexander S AS Gelman Andrew E AE Miller Mark J MJ Kreisel Daniel D
Journal of immunology (Baltimore, Md. : 1950) 20150311 8
Neutrophils are critical mediators of innate immune responses and contribute to tissue injury. However, immune pathways that regulate neutrophil recruitment to injured tissues during noninfectious inflammation remain poorly understood. DAP12 is a cell membrane-associated protein that is expressed in myeloid cells and can either augment or dampen innate inflammatory responses during infections. To elucidate the role of DAP12 in pulmonary ischemia/reperfusion injury (IRI), we took advantage of a c ...[more]