Ontology highlight
ABSTRACT:
SUBMITTER: Sundaresan NR
PROVIDER: S-EPMC4401084 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sundaresan Nagalingam R NR Vasudevan Prabhakaran P Zhong Lei L Kim Gene G Samant Sadhana S Parekh Vishwas V Pillai Vinodkumar B VB Ravindra P V PV Gupta Madhu M Jeevanandam Valluvan V Cunningham John M JM Deng Chu-Xia CX Lombard David B DB Mostoslavsky Raul R Gupta Mahesh P MP
Nature medicine 20121021 11
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transg ...[more]