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DLC-1:a Rho GTPase-activating protein and tumour suppressor.

ABSTRACT: The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia.

SUBMITTER: Durkin ME

PROVIDER: S-EPMC4401278 | biostudies-literature | 2007 Sep-Oct

REPOSITORIES: biostudies-literature

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DLC-1:a Rho GTPase-activating protein and tumour suppressor.

Durkin Marian E ME Yuan Bao-Zhu BZ Zhou Xiaoling X Zimonjic Drazen B DB Lowy Douglas R DR Thorgeirsson Snorri S SS Popescu Nicholas C NC

Journal of cellular and molecular medicine 20070901 5

The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of D ...[more]

PMID: 17979893

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