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Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures.

ABSTRACT: Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on 927 psoriasis cases and 3,717 controls. After controlling for major confounders, in the cross-sectional analysis psoriasis was significantly associated with type 2 diabetes (T2D, adjusted odds ratio (OR)=2.36; 95% confidence interval CI=1.26-4.41) and myocardial infarction (MI, OR=2.26; 95% CI=1.03-4.96). In the longitudinal study, psoriasis slightly increased the risk for incident T2D (adjusted relative risk (RR)=1.11; 95% CI=1.08-1.14) and MI (RR=1.14; 95% CI=1.06-1.22), with highest risk increments in systemically treated psoriasis, which accounted for 11 and 17 excess cases of T2D and MI per 10,000 person-years. Except for weak signals from within the major histocompatibility complex, there was no evidence of genetic risk loci shared between psoriasis and cardiometabolic traits. Our findings suggest that psoriasis, in particular severe psoriasis, increases the risk for T2D and MI, and that the genetic architecture of psoriasis and cardiometabolic traits is largely distinct.

SUBMITTER: Koch M

PROVIDER: S-EPMC4402117 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures.

Koch Manja M Baurecht Hansjörg H Ried Janina S JS Rodriguez Elke E Schlesinger Sabrina S Volks Natalie N Gieger Christian C Rückert Ina-Maria IM Heinrich Luise L Willenborg Christina C Smith Catherine C Peters Annette A Thorand Barbara B Koenig Wolfgang W Lamina Claudia C Jansen Henning H Kronenberg Florian F Seissler Jochen J Thiery Joachim J Rathmann Wolfgang W Schunkert Heribert H Erdmann Jeanette J Barker Jonathan J Nair Rajan P RP Tsoi Lam C LC Elder James T JT Mrowietz Ulrich U Weichenthal Michael M Mucha Sören S Schreiber Stefan S Franke Andre A Schmitt Jochen J Lieb Wolfgang W Weidinger Stephan S

The Journal of investigative dermatology 20150119 5

Psoriasis has been linked to cardiometabolic diseases, but epidemiological findings are inconsistent. We investigated the association between psoriasis and cardiometabolic outcomes in a German cross-sectional study (n=4,185) and a prospective cohort of German Health Insurance beneficiaries (n=1,811,098). A potential genetic overlap was explored using genome-wide data from >22,000 coronary artery disease and >4,000 psoriasis cases, and with a dense genotyping study of cardiometabolic risk loci on ...[more]

PMID: 25599394

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Dataset Information

Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures.

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Psoriasis and cardiometabolic traits: modest association but distinct genetic architectures.

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