Ontology highlight
ABSTRACT:
SUBMITTER: Williams LH
PROVIDER: S-EPMC4402150 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Williams Lucy H LH Fromm George G Gokey Nolan G NG Henriques Telmo T Muse Ginger W GW Burkholder Adam A Fargo David C DC Hu Guang G Adelman Karen K
Molecular cell 20150312 2
The remarkable capacity for pluripotency and self-renewal in embryonic stem cells (ESCs) requires a finely tuned transcriptional circuitry wherein the pathways and genes that initiate differentiation are suppressed, but poised to respond rapidly to developmental signals. To elucidate transcriptional control in mouse ESCs in the naive, ground state, we defined the distribution of engaged RNA polymerase II (Pol II) at high resolution. We find that promoter-proximal pausing of Pol II is most enrich ...[more]