Ontology highlight
ABSTRACT:
SUBMITTER: Hirata E
PROVIDER: S-EPMC4402404 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Hirata Eishu E Girotti Maria Romina MR Viros Amaya A Hooper Steven S Spencer-Dene Bradley B Matsuda Michiyuki M Larkin James J Marais Richard R Sahai Erik E
Cancer cell 20150401 4
Intravital imaging of BRAF-mutant melanoma cells containing an ERK/MAPK biosensor reveals how the tumor microenvironment affects response to BRAF inhibition by PLX4720. Initially, melanoma cells respond to PLX4720, but rapid reactivation of ERK/MAPK is observed in areas of high stromal density. This is linked to "paradoxical" activation of melanoma-associated fibroblasts by PLX4720 and the promotion of matrix production and remodeling leading to elevated integrin β1/FAK/Src signaling in melanoma ...[more]