Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC4402509 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Deng Xutao X Naccache Samia N SN Ng Terry T Federman Scot S Li Linlin L Chiu Charles Y CY Delwart Eric L EL
Nucleic acids research 20150113 7
Next-generation sequencing (NGS) approaches rapidly produce millions to billions of short reads, which allow pathogen detection and discovery in human clinical, animal and environmental samples. A major limitation of sequence homology-based identification for highly divergent microorganisms is the short length of reads generated by most highly parallel sequencing technologies. Short reads require a high level of sequence similarities to annotated genes to confidently predict gene function or hom ...[more]