Ontology highlight
ABSTRACT:
SUBMITTER: Roy CN
PROVIDER: S-EPMC4403036 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Roy Chandra Nath CN Khandaker Irona I Furuse Yuki Y Oshitani Hitoshi H
Bioinformation 20150331 3
HIV-1Tat (trans-acting activator of transcription) plays essential roles in the replication through viral mRNA and genome transcription from the HIV-1 LTR promoter. However, Tat undergoes continuous amino acid substitutions. As a consequence, the virus escapes from host immunity indicating that genetic diversity of Tat protein in major HIV-1 subtypes is required to be continuously monitored. We analyzed available full-length HIV-1 sequences of subtypes B (n=493) and C (n=280) strains circulating ...[more]