Ontology highlight
ABSTRACT:
SUBMITTER: Farinha A
PROVIDER: S-EPMC4403101 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Farinha A A Lavreysen H H Peeters L L Russo B B Masure S S Trabanco A A AA Cid J J Tresadern G G
British journal of pharmacology 20150227 9
<h4>Background and purpose</h4>The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these receptors' function and are being investigated as a novel therapeutic approach. An extensive set of mutant human mGlu2 receptors were used to investigate the molecular de ...[more]