A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
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ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC4403379 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu Jianning J Luo Ceng C Bali Kiran Kumar KK Xie Rou-Gang RG Mains Richard E RE Eipper Betty A BA Kuner Rohini R
Nature communications 20150413
Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity- ...[more]
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