Ontology highlight
ABSTRACT:
SUBMITTER: Berger CT
PROVIDER: S-EPMC4403399 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Berger Christoph T CT Llano Anuska A Carlson Jonathan M JM Brumme Zabrina L ZL Brockman Mark A MA Cedeño Samandhy S Harrigan P Richard PR Kaufmann Daniel E DE Heckerman David D Meyerhans Andreas A Brander Christian C
Journal of virology 20150114 7
Cytotoxic-T lymphocyte (CTL) responses to epitopes in alternative HIV reading frames have been reported. However, the extent of CTL responses to putative proteins encoded in antisense reading frames is unknown. Using sequence alignments and computational approaches, we here predict five potential antisense HIV proteins and characterize common CTL responses against them. Results suggest that antisense-derived sequences are commonly transcribed and translated and could encode functional proteins t ...[more]