HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.
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ABSTRACT:
SUBMITTER: Baird NA
PROVIDER: S-EPMC4403873 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.
Baird Nathan A NA Douglas Peter M PM Simic Milos S MS Grant Ana R AR Moresco James J JJ Wolff Suzanne C SC Yates John R JR Manning Gerard G Dillin Andrew A
Science (New York, N.Y.) 20141001 6207
The conserved heat shock transcription factor-1 (HSF-1) is essential to cellular stress resistance and life-span determination. The canonical function of HSF-1 is to regulate a network of genes encoding molecular chaperones that protect proteins from damage caused by extrinsic environmental stress or intrinsic age-related deterioration. In Caenorhabditis elegans, we engineered a modified HSF-1 strain that increased stress resistance and longevity without enhanced chaperone induction. This health ...[more]
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