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HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study.

ABSTRACT: HNF1B (formerly known as TCF2) gene encodes for a transcription factor that regulates gene expression involved in normal mesodermal and endodermal developments. A close association between rs4430796 polymorphism of HNF1B gene and decreased endometrial cancer (EC) risk has been demonstrated. The aim of the current study was to test the hypothesis that rs4430796 polymorphism can influence the prognosis of EC patients.Retrospective cohort study. Clinical and pathological data were extrapolated and genotypes were assessed on formalin-fixed and paraffin-embedded non-tumour tissues. The influence of patients' genotype on overall survival and progression free survival were our main outcome measures.A total of 191 EC patients were included in the final analysis. Overall survival differed significantly (P?=?0.003) among genotypes. At multivariate analysis, a significant (P?

SUBMITTER: Mandato VD 

PROVIDER: S-EPMC4403886 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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<h4>Background</h4>HNF1B (formerly known as TCF2) gene encodes for a transcription factor that regulates gene expression involved in normal mesodermal and endodermal developments. A close association between rs4430796 polymorphism of HNF1B gene and decreased endometrial cancer (EC) risk has been demonstrated. The aim of the current study was to test the hypothesis that rs4430796 polymorphism can influence the prognosis of EC patients.<h4>Methods</h4>Retrospective cohort study. Clinical and patho  ...[more]

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