Ontology highlight
ABSTRACT:
SUBMITTER: Khuperkar D
PROVIDER: S-EPMC4403925 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150420 4
Ran, a member of the Ras-GTPase superfamily, has a well-established role in regulating the transport of macromolecules across the nuclear envelope (NE). Ran has also been implicated in mitosis, cell cycle progression, and NE formation. Over-expression of Ran is associated with various cancers, although the molecular mechanism underlying this phenomenon is unclear. Serendipitously, we found that Ran possesses the ability to move from cell-to-cell when transiently expressed in mammalian cells. Mor ...[more]